She Kills Monsters is set in the present day, primarily taking place in the real world and within a fantastical Dungeons & Dragons-inspired game realm. The story follows Agnes, a grieving woman who embarks on a journey through her late sister’s role-playing game, discovering a hidden world of monsters, warriors, and magic. The show juxtaposes the modern, everyday setting with the vivid, imaginative fantasy world, blending the two time periods to explore themes of loss, identity, and self-discovery. The play's setting shifts between contemporary suburban life and the epic, mythical universe of the game, offering a dynamic contrast that enhances the story's emotional depth and adventure.